Decomposition of Ƒ ¿ - Tocopheryl Spirodimer
نویسنده
چکیده
An alkaline saponification method containing pyrogallol is usually applied for the determination of tocopherols. Although there are some metabolites of ƒ¿-tocopherol in tissues, it is not yet clear whether they are true metabolites or degradation products from the alkaline saponi fication. Since it was shown that ƒ¿-tocopheryl spirodimer, a metabolite of ƒ¿-tocopherol, was degraded mainly to a substance positive to Emmerie Engel reagent, the identification of this substance was carried out . As the model compound of ƒ¿-tocopherol (ƒ¿-T), mainly 2, 2, 5, 7 , 8-penta methyl-6-hydroxy-chromane (M) was used . The results obtained showed that spirodimers of ƒ¿-T and M were reduced to the corresponding di hydroxydimers with pyrogallol during the saponification . Therefore, it was suggested that the alkaline saponification method could not be applied to detect the metabolites from ƒ¿-T and related compounds .
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